BCG 2nd Edition -TB vaccine- Application against tuberculosis and other diseases
Takemasa Takii, Ph.D.
Jun-ichi Maeyama, Ph.D.
Ten yeas have passed since the publication of the first edition, and there have been many advances in our understanding of the BCG vaccine. Hence, we added contents about the safety and use of the BCG vaccine and its application to other diseases in this second edition, in addition to a revision of the contents of the first edition. The authors of this book are experts in the fields of BCG and TB research.
This book is the only book that covers basic, clinical and epidemiologic studies of the BCG vaccine systematically. No other book covers the TB vaccine so comprehensively, from its birth up to future vaccine development. Finally, TB is not a past disease and has not been eradicated yet, it can still be considered a pandemic. We would be extremely thankful if this book is useful for persons engaged in the eradication of TB by helping them futher their understanding of the TB vaccine and its future prospects.
Chapter 1 Historical background of Mycobacterium bovis BCG Mary Jackson and Saburo Yamamoto Chapter 2 BCG vaccination in control of tuberculosis Toru Mori Chapter 3 BCG characterization Mei Mei Ho Chapter 4 Report of the efficacy and safety for percutaneous use of BCG vaccine prepared from Tokyo 172-1 strain Shizuko Nakata, Katsutoshi Oshima, Naoki Nakada, et al Chapter 5 Adverse reactions after vaccination with Bacille Calmette-Guérin Osamu Tokunaga Chapter 6 Animal models in BCG-induced resistance to tuberculosis David N. McMurray Chapter 7 Immunological characteristics of two subpopulations of BCG Tokyo 172 with different RD16 regions in a guinea pig model of pulmonary tuberculosis Toshiko Yamamoto, Christine McFarland, Lan Ly, et al Chapter 8 Lipid phenotypes of BCG strains and their host responses Nagatoshi Fujiwara Chapter 9 Development of new TB vaccines Takemasa Takii Chapter 10 Recombinant BCG vaccines Kazuhiro Matsuo Chapter 11 Toxicity study for BCG Tokyo, Danish, and Pasteur substrains in SCID mice Kazuhiro Matsuo Chapter 12 Mechanisms of action of intravesical BCG therapy for nonmuscle invasive bladder cancer Timothy L. Ratlif Chapter 13 Beneficial off-target effects of the BCG vaccine: type 1 diabetes and beyond Hiroyuki Takahashi and Denise L. Faustman Chapter 14 Bacterial factors regulating M. tuberculosis infection and persistence Akihito Nishiyama and Sohkichi Matsumoto Chapter 15 Host and bacterial factors regulating Mycobacterium tuberculosis infection and persistence Yuriko Ozeki, Mamiko Niki, and Sohkichi Matsumoto Chapter 16 Genetic diversity of Mycobacterium tuberculosis and its impact on adaptive evolution, vaccination efficacy, and population dynamics Takayuki Wada Chapter 17 Efficacy of BCG vaccination against leprosy and nontuberculous mycobacteria (NTM) infections Naoya Ohara Chapter 18 Administration methods of BCG vaccine and adjuvants Jun-ichi Maeyama